All three are main characters but the story is about Yuki and Kaname so in Vampire Knight Guilty and the first series is about Yuki so Yuki starts out as the main character then ends up sharing the spotlight with Kaname later.
posted over a year ago
The first season of the anime featured a lot of Zero though, then Kaname came more into prominence later. And they swap around like that throughout the manga too. I'd say those 2 were equal, with Yuuki slightly more main than her two love interests.
